Who will seal a top-four spot? There's a Champions League shootout between Leicester and Man Utd in store, while Chelsea will be hoping to do their bit and get at least a point against Wolves.
And what about the scrap to stay in the Premier League? It's gone down to the final day and only one of Bournemouth, Watford and Aston Villa will be reprieved.
There's plenty to play for elsewhere too, from valuable prize money to the Golden Boot trophy.
Expect tension, expect drama but, wherever you're following, you can be sure we'll guide you through every twist and turn here on our Live Update feed.
All games start at 3pm GMT.
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