The Reds top the table after four games, having preserved their 100 per cent winning record with a victory over Leicester City last time out while Spurs suffered a 2-1 defeat at high-flying Watford.
London has been a happy hunting ground for Jurgen Klopp since taking over at Liverpool. The German has seen his side win nine of their 15 trips to the capital in the league but they're yet to win against Tottenham.
Last season the Reds took only one point from five trips to their fellow top six sides. That might put off some who would normally back them in the match odds market, but their defence has improved markedly with the acquisition of Alisson.
Although the goalkeeper was at fault for the goal his side conceded at the King Power Stadium, it was the first in four matches so far this term.
There have been 149 scored in head-to-head meetings between them in the Premier League, the second most in the competition behind Arsenal v Everton (151). The 22 penalties awarded in this fixture is also the most of any matchup in Premier League history.
A win for the Reds will extend their lead on the table whiles a win for Spurs would see them move a notch higher above their current 5th place spot.
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