The Phobians will play host to the Porcupine Warriors at the Accra Sports Stadium, a game many have touted as a title decider.
Both Hearts of Oak and Asante Kotoko go into the match tied on 56 points.
A scoreless stalemate would see Hearts of Oak maintain their lead at the table.
However, Asante Kotoko will leapfrog their rivals with a scoring draw due to the head-to-head record after playing goalless stalemate in the reverse fixture in February.
Ahead of the game, Footballghana.com takes a look at the last five games for both clubs.
Below are the last five games of Hearts and Kotoko:
Accra Hearts of Oak:
Hearts of Oak 3-0 Liberty Professionals
Great Olympics 1-1 Hearts of Oak
Hearts of Oak 2-0 Medeama
Hearts of Oak 4-1 Windy Professionals
Legon Cities 1-2 Hearts of Oak
Asante Kotoko
BYF Academy 0-2 Kotoko
Kotoko 1-0 Ashantigold
Inter Allies 2-3 Kotoko
Thunderbolts 1-3 Kotoko
Kotoko 2-1 Karela United
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